Travel to modern Cuba with the thriller, MALIGNANCY

When you think of #Cuba, do you think of vintage cars, cigars, beaches, the rich blending of Spanish and West African traditions in Cuban music, Castro, and the U.S. embargo of Cuba? That what I thought before I visited Cuba. 

During a visit to Cuba, I quickly became tired of reverential references to Che Guevara, didn’t think much of La Floridita (the bar made famous by Hemingway), and found their vintage cars amusing at best. However, I was impressed by the innovative nature of the Cuban people as they skirted the U. S. embargo of Cuba and Cuban laws. For example, did you know Cuban government patented one of the first cancer immunotherapy drugs (Racotumomab)? Granted the Cuban researchers spent much of their time at Harvard and the patent was filed with scientists in Argentina, but that’s another story.

I tried to present readers with an honest view of modern Cuba in the fast paced #thriller, Malignancy. The story begins in New Mexico. Men disguised as police officers shoot at Sara Almquist twice in one day. The Albuquerque Police suspect a drug czar with a vendetta against Sara. Thus, when colleagues in the State Department invite Sara, an experienced scientist, to arrange scientific exchanges between the U.S. and Cuba, she jumps at the chance to escape. Both fortunately and unfortunately, Sara learns more about scientists in Cuba and her so-called American colleagues than she expected. 

Available at: https://www.amazon.com/Malignancy-Science-Traveler-J-Greger/dp/0960028528/https://www.amazon.com/Malignancy-Science-Traveler-J-Greger/dp/0960028528/

Mystery Writers Are Like Scientists

 Writing a mystery novel is similar to conducting a science experiment in several ways.

·      Writers and scientists both do research.

·      They both organize their observations into a whole, which writers call plots and scientists call hypotheses.

·      They both test and refine their “whole.” Writers edit their prose; scientists run additional experiments.

·      Both require a lot of hard work to gain occasional flashes of insights. To paraphrase Thomas Edison, they’re “one percent inspiration and ninety-nine percent perspiration.”

Why did I drag you through this discussion? I’m trying to explain why so many scientists and physicians became writers of mysteries and thrillers. Consider Michael Crichton (a physician by training), Kathy Reichs (a forensic anthropologist), Robin Cook (a physician). I’m also explaining how as a retired biology professor I came to write mystery/suspense novels with tidbits of science.

Through this discussion, I hope you learn how bits of science add realism to a mystery.

Let’s start with my thriller, I Saw You in Beirut. In this thriller, a woman’s past provides clues for the extraction of a nuclear scientist from Iran (http://www.amazon.com/dp/1610092201).

Did you know? In the early 1960s, scientists identified zinc deficiency in peasants in Iran. At that time, two to three percent of the villagers in some regions of Iran didn't pass the physical for the army because of stunted growth. Dr. James Halstead, Sr. who was married to President’s Roosevelt’s daughter, Anna, headed the research team at Shiraz. Surprised?

I created Doc Steinhaus, a fictional character in I Saw You in Beirut, who worked on the project in Shiraz as a grad student. He was a logical way to “show not tell” readers about science in Iran and advance the plot. Let’s face it most foreign agents don’t look or act like James Bond, but they can be a lot more nuanced.

 

Now how about Malignancy? In this suspense novel, a woman scientist tries to escape the clutches of a drug lord and accepts a risky assignment in Cuba (http://amzn.com/1610091779.

When I visited Cuba in 2013, I learned Cuban researchers had patented a therapeutic cancer vaccine to treat non-small cell lung cancer. This drug revs up a patient’s own immune system to produce cells, which recognize substances found on the surface of tumor cells but not on the surface of normal cells, and kills the cancer cells. For those surprised about the sophistication of this work, please note the researchers had spent a lot time at Harvard despite the embargo.

I also read the editorial in Science (6/6/2014) on scientific exchanges between the U.S. and Cuba. I thought Sara Almquist, as an epidemiologist and heroine of my previous medical thrillers Coming Flu (http://amzn.com/1610090985 and Ignore the Pain (http://amzn.com/1610091310), would be the perfect protagonist to do a little “scientific diplomacy” in Cuba.

Of course, Sara gets involved in a lot more than science in both novels; they wouldn’t be thrillers without danger. Why don’t you read them and learn a little thrilling science?

IS IT FACT OR FICTION?

 Or to put it another way—when does a memoir or biography become fiction? I like books labeled as non-fiction to be just that, but I like lots of facts in fiction.

I’m sure many of you will disagree with me because you love to escape into a different world when you read. However, Downton Abbey would lose its zing if costumes, sites, and key historic events in WWI and the flu epidemic of 1918 weren’t described correctly. Even fantasy novels are enhanced by a few facts. The evacuation of children to from London during the Nazi blitzkrieg is the basis of CS Lewis’s Chronicles of Narnia.

Points to consider when including facts in fiction

1. Create a strong plot, and #insert facts to create realistic characters.

I’ll give an example from Malignancy. In this thriller, a woman scientist tries to escape the clutches of a drug lord and accepts a State Department assignment to set up scientific exchanges between the U.S. and Cuba. However, the scientific community is less safe than she expected.

That’s the plot. One of Sara’s surprises is Cuban researchers have patented a vaccine that is thought to strengthen patients’ immune response against a certain type of lung cancer. (Fact: The cancer vaccine Racotumomab is in clinical trials now world wide.). Other surprises involve her love interest and the dug czar. They are not based on facts. The scientific facts allow me to show Sara’s expertise and ingenuity. They also keep her from being a busy body, who wouldn’t be included in real exchanges among “diplomats” from Cuba and the U.S.

2. Pick #relevant and exciting topics.

A great author can make any topic interesting but most of us aren’t great writers. Readers are more apt to be interested in tales based on intrinsically interesting issues—global warming or curing cancer. Michael Chrichton (Jurassic Park), Robin Cook (Coma), and Ian McEwan (Solar) were particularly skillful at selecting scary high-tech issues for their thrillers.

3. #Use facts to turn locations into strong characters.

Realistic locations improve any novel. Hemingway’s The Sun Also Rises would be pretty boring without the hypnotic descriptions of the Festival of San Fermín in Pamplona. The decadence and beauty of Venice set the mood for Thomas Mann’s Death in Venice. The Cuba (I visited three years ago and depicted in Malignancy) is surprising and probably transient.

4. Be as accurate as possible.

A writer of thrillers told me recently that readers accept a couple inaccuracies in a novel if you have stated most of the information correctly. I don’t know if that’s true. Certainly, Dan Brown has been criticized for inaccurate historical information in his best selling novel, The DaVinci Code, but he certainly included enough facts to ignite readers’ interest.

Why not pick up copies of Malignancy and see if you like facts in fiction, too? Malignancy won first prize in the 2015 Public Safety Writers annual contest.

Malignancy is available at Amazon http://amzn.com/1610091779

Does Your Writing Bark, Purr, or Neigh?

A recent poll of users of social media had a bit to say about pets. Almost two-thirds of pet owners claim they post two comments or photos of their pets on social media weekly. Half of these pet owners claim photos and notes on pets draw more comments and likes than their other posts.

Are these bits of trivia relevant to fiction writers?

I think there are at least three reasons for including animals in novels.    

 Authors may increase the appeal of their novels to a wider audience by including dogs, cats, and other pets in their tales (Pun intended.). Consider all the cozy novels built around clever dogs and cats. Come to think of it, Westerns would be pretty blah without horses.

·       Authors can often show a different side of human characters in their novels by allowing characters to talk to or interact with their pets. Asta in Dashiell Hammett’s The Thin Man, Cat in Truman Capote’s Breakfast at Tiffany’s, and Argos in Homer’s The Odyssey demonstrate pets belong in serious adult fiction.

·       Pets are fun to write about. I enjoy including Bug, my Japanese Chin, in my thriller series (Coming Flu, Ignore the Pain, Malignancy, and I Saw You in Beirut). Besides being beautiful, he’s smart. He deserves attention for his work as pet therapy at local hospitals for more than eight years. (Don’t I sound like the typical pet owner in the survey?) And he definitely allows me to show a soft side to my world-traveling scientist and heroine, Sara Almquist.

 

Maybe, you should include a dog or cat in your next novel. Or be creative and give your human character a more unusual alter ego, like a fish, raccoon, or elephant. 

All my books (paperback & Kindle versions are available on Amazon.

• In I Saw You in Beirut, a woman’s past provides clues for the extraction of a nuclear scientist from Iran. http://www.amazon.com/dp/1610092201

• In Malignancy, a woman scientist tries to escape the clutches of a drug lord and accepts a risky assignment in Cuba. http://amzn.com/1610091779

• In Ignore the Pain, an epidemiologist learns too much about the coca trade and too little about a sexy new colleague while on a public health assignment in Bolivia. http://amzn.com/1610091310

• In Coming Flu, is the Philippine flu or a drug kingpin caught in a quarantine is more deadly? http://amzn.com/1610090985

DORIAN GRAY REVISITED

Oscar Wilde in The Picture of Dorian Gray said, “The only thing worse than being talked about is not being talked about.” Was he right? All publishers seem to agree publicity (now politely called a platform) is necessary for sales.

Is publicity really just a form of advertising?

That question demonstrates I’m no expert on communications and perhaps a bit cynical. Here’s what one expert said, “Advertising and publicity are two very different communication tools, even though both employ the mass media as a vehicle for reaching large audiences… Advertising buys its way into the media… Publicity is presented by the media because it's newsworthy."

What works in advertising?

Probably millions of words have been written on the topic. These two ideas may be useful to authors.

1. Extend engagement. Consumers are more apt to buy a product if they spend more time looking at an ad or better still interacting with the advertiser.

Accordingly, I am starting a CONTEST: WIN A CHANCE TO BE A CHARACTER IN MY NEXT NOVEL. To enter, post a comment to this blog or any of my guest blogs during the next six months. I’ll draw the winner out of a hat and name a character after them in an upcoming book in my thriller series.

2. Associate your writing with things readers like. Advertising often sells products not by providing factual information but by surrounding the product with other things shoppers liked (like cute pets in toilet paper ads).

I suspect that’s why so many novelists write blogs. They’re trying to tempt readers with a slightly funny blog.

Many readers would love to travel to exotic spots, but lack the cash and maybe the guts to face long flights, endless lines, and questionable food. That’s why I have my heroine Sara Almquist travel to Bolivia in Ignore the Pain, Cuba in Malignancy, and Lebanon and Qatar in I Saw You in Beirut. Should I send Sara to India or Laos in my next novel? Which country would you rather visit vicariously?

Please extend your interaction with this author and leave a comment. Thanks.

P.S. DID YOU NOTICE I PUT A PICTURE OF BUG AT THE START, SO YOU'D THINK POSITIVELY?

Here are thumbnail sketches of international adventures with a middle-aged woman. Maybe, I shouldn’t use the words (middle-aged) because it isn’t a pleasant thought to many. However, I suspect her views are closer to most readers’ attitudes than those of James Bond.

See BOLIVIA in Ignore the Pain, as public health consultant, Sara Almquist, learns too much about the coca trade and too little about sexy undercover agent Xave Zack.

Available at Amazon: http://amzn.com/1610091310 and on Nook: http://www.barnesandnoble.com/w/ignore-the-pain-j-l-greger/1117532777;jsessionid=C54A000FC8C6FFBE5237D52396D7B8C6.prodny_store01-atgap03?ean=2940157799212

 

Visit CUBA in Malignancy, when Sara Almquist arranges scientific exchanges

between the US and Cuba and learns more about undercover agent Xave Zack.

Available at Amazon: http://amzn.com/1610091779 and on Nook: http://www.barnesandnoble.com/w/malignancy-jlgreger/1123390529?ean=2940157827649

Explore LEBANON, QATAR, and THE EMERATES with Sara in I Saw You in Beirut. Her past has the clues for the rescue of a nuclear scientist from Iran.

Available at Amazon: http://www.amazon.com/dp/1610092201 and on Nook: http://www.barnesandnoble.com/w/i-saw-you-in-beirut-jl-greger/1123184446?ean=2940158046957

Perseverance Pays in Writing

My most recent medical thriller set partially in Cuba, MALIGNANCY, won first prize in the published novel category in the Public Safety Writers Association (PSWA) annual writing contest.

During the last seven years, I've had four of my novels and a couple of short stories published. This is the first time I won in a writing contest. Here's my advice to other writers. I suppose it's presumptuous to give advice, but I may not have this opportunity to "speak from successful experience" again.

1) Write every day. My definition of writing includes: researching topics, composing text, editing, and publicizing the work. The advantage of writing even a few lines every day is you are forced to think about your plot, characters, and style frequently.

2) Organize your writing. I don't think you have to prepare a detailed outline before you write, but create a running list of characters as you write anything longer than flash fiction. Include a short profile of each character ion your list. This prevents a blue-eyed beauty, who never cries, from having tears well up in her brown eyes. A timeline is also helpful, especially during the editing process.


3) Edit. I know a few authors claim they only need to edit their work once; I'm not that good. I think there are three general categories of editing.  

These questions should be considered during a content edit . Are the scientific facts clear and correct? Are locations described vividly and accurately? Are the characters interesting and consistent? Do major character "grow" during the arc of the story? Is the timeline realistic?

 The style edit is hard to define but important. Novels are generally more interesting if dialogue, action sequences, and psychological development of characters are interspersed so that the pace of the novel varies.The point of view should be clear in each chapter or scene.

The edit for word choices, grammar, and typos often seems like an endless process. I try to reduce the use of "overused " words, replace weak verbs with action ones, tweak sentences to be active not passive, and check for spelling and grammar errors (which I euphemistically call typos) several times.

4) Hire a professional editor. I'm always amazed how much they discover after I finish my edits.

5) Try a variety of promotion techniques. Recognize when certain venues fail, and either fix the situation or move on to another format. Read criticism and less than glowing reviews several times. I usually learn more than I care to admit.  

6) Persevere.

Hopefully, you'll want to read MALIGNANCY and feel the tension as a woman scientist tries to escape the clutches of a drug lord in New Mexico and accepts a risky assignment in Cuba. Besides the excitement, you'll learn a bit about modern Cuba and new immunotherapy cancer drugs.

http://amzn.com/1610091779 Kindle: B00QG7SZ58

Writers can learn from DESIGN THINKING

Stanford University’s D.School (more correctly the Hasso Plattner Institute for Design) wants to foster design thinking - a methodology for producing reliably innovative results in any field, not just product development.

This could be considered another university attempt to foster creative thinking in education and scholarship outside traditional disciplinary boundaries. But it might also be a wake up call to writers.

The design philosophy is based on seven principles, which also are good advice to writers.

1. Show don’t tell. We've all heard that advice a hundred times.
2. Focus in human values. We know character development is central to any good novel.
   
3. Craft clarity. We know we should edit out excess adverbs and dangling phrases.
4. Embrace experimentation. Most of us stick with what works. Maybe we should try something different more often, such as write in the first person instead of the third person, write short stories instead of novels, or pick a different type of cover.
   
5. Be mindful of process. Edit, edit, edit.
6. Bias toward action. Showing action is better than conversation many times. Or another interpretation could be: write at least a page every day on your novel instead of just talking about writing.
7. Radical collaboration. I had trouble translating this one into advice for writers. Maybe it's find a new editor, writer's group, or publisher.

Perhaps the real message is effective communication share certain characteristics despite the format. 

I think this design thinking would be helpful for anyone contemplating revising and editing their novels for a second edition.

 How would you interpret DESIGN THINKING into advice for authors?

 

Do you want to write a medical thriller or mystery?

Has the nightly TV news made you think about writing a novel on an Ebola or measles epidemic?

#The first step in writing is a medical thriller is research.

This type of research needs depth and breadth. Not surprisingly, many medical and scientific thrillers have been written by physicians or scientists, like Robin Cook, Michael Crichton, Kathy Reichs, and myself.

Let me explain what depth and breadth means. Someone (If I tell you who it will ruin the mystery.) “poisons” a diet doctor in Murder: A New Way to Lose Weight. This toxin was the cause of a rash of real poisonings in New Mexico in the 1980s. I wove the information from two scientific articles into my tale of an intentional poisoning and set the novel in Albuquerque as an oblique clue.

To add authenticity to all my medical mysteries/thrillers, I reference key articles in the “Scientific Epilogues” of each novel.

How did I find such arcane articles? I read articles on science and medicine in newspapers and magazines and on line. I also read scientific journals, especially the journal Science, and look for trends. For example, the dead diet doctor had been studying ways to modify the bacteria in the guts of obese subjects as a way to help them lose weight. I thought this research had humorous aspects and is a promising area of research.

#The second step in writing medical mysteries is creating a filing system that allows retrieval of articles by several headings.

If you're not careful, all your research becomes a lot of clutter. So I cross-reference materials I stash in real and virtual files carefully. I note not only the medical or scientific issue discussed in articles but also the location (if outside the U.S. or in New Mexico) where the research was done and the possible social significance of the work.

For example, I’ve had files on Ebola and other tropical diseases for twenty years ago. No, I don’t plan to write a novel on Ebola, but I know these articles are good sources of information on the problems faced by health care workers during epidemics and the responses of citizens to quarantines.

# The third step in writing a medical novels is basically scientific education.

It’s finding clear ways to explain complex issues in human terms.

Among the propaganda spouted by Cuban tour guide in 2013 was the statement: Cuban scientists had patented a drug for cancer. When I got home, I investigated her claim and found researchers in Havana had patented a therapeutic cancer vaccine to treat a rather rare type of lung cancer (non-small cell). This drug revs up a patient’s own immune system to produce cells, which recognize substances found on the surface of tumor cells but not on the surface of normal cells. These immune cells then slay the cancer cells, but not the normal cells.

Okay that’s a heavy dose of science. What’s the social relevance? This patent demonstrates several Cuban scientists are doing competitive science, and the Cuban government understand the importance of commercialization of their research. I also discovered U.S. scientists were trying to augment existing scientific exchanges between the U.S. and Cuba, despite the embargo on Cuba. (Editorial in the journal Science on June 6, 2014.)

I thought Sara Almquist, as an epidemiologist and heroine of my previous medical thrillers Coming Flu and Ignore the Pain, would be the perfect protagonist to do a little “scientific diplomacy” in Cuba. The result is my thriller Malignancy. Of course, Sara gets involved in a lot more than science; it wouldn’t be a thriller without danger.

So are you ready to write a medical mystery or thriller?

Real Science Is Essential in Mysteries & Thrillers

Laboratory results, psychology, and computer analyses are essential for plot development in any modern mystery or crime fiction. Think of the TV shows—CSI, NCIS, and Criminal Minds. Many thrillers depend on technologically to provide innovative ways to trap or destroy villains. Big Bang Theory has shown science nerds can be funny. However, many authors (especially those who are not scientists or physicians) are uncomfortable about using scientific tidbits in their writing.

Essential considerations when adding science to fictional tales.

1) Use scientific details to create realistic scenes, but not so many as to slow the plot. As a biologist, who regularly reads scientific journals, I’m intrigued by cancer immunotherapy. (Scientists are making vaccines that trigger the immune systems of cancer patients to more effectively fight their disease.) That’s the scientist in me talking. The novelist part of me says the plot and character development rule.

In Malignancy, men disguised as police officers shoot at Sara Almquist twice in one day. Albuquerque police suspect Jim Mazzone, a drug czar who has tangled with Sara before, will order more hits on Sara. When colleagues in the State Department invite Sara to arrange scientific exchanges between the U.S. and Cuba, she jumps at the chance to get out of town. Soon, she realizes Cuba offers more surprises than Albuquerque.

That’s the plot. One of Sara’s surprises is Cuban researchers have patented a therapeutic vaccine for a certain type of lung cancer (actual fact). Another surprise involves her love interest, the shady Xave Zack. I can’t tell you about the others because that would spoil your surprises as a reader.

2)  Pick relevant science topics. Readers are more apt to be interested in facts that are relevant to real issues—global warming, fracking for natural gas, or curing cancer than in learning details about biochemical pathways.

I thought weights control was one of universal interest to Americans, but most want to hear something besides the obvious: eat less and exercise more. Scientist know fat animals (including humans) lose weight when their gut bacteria are altered, but scientists don’t know which of the 15,000 to 36,000 species of bacteria in the gut are important. Talk about a lot of red herrings. I thought descriptions of this research (based on current ongoing studies) would be intriguing, maybe slightly funny, to readers.

In Murder: A New Way to Lose Weight, a diet doctor is found dead after she charges her partner with recklessly endangering the lives of obese subjects in their clinical trials. Linda Almquist, the associate dean in the medical school, must protect the subjects in the clinical trial, while she searches for a sophisticated killer who knows a lot about poisons.

3) Be accurate. In Malignancy, I state the truth about the cancer vaccine Racotumomab developed by the Cubans. It triggers patients’ bodies to mount an immune response against of certain types of lung tumor cells because they have an unusual compound on their surface. It doesn’t prevent or cure cancer, but in it should slow the progression of the disease. It may be one of the first successes in cancer immunotherapy, but it’s too soon to tell. Many clinical trials, which require international cooperation of scientists and physicians, are need. Thus this is a practical example of why the State Department sent my heroine, a scientist, to Cuba to begin to set up exchanges Cuban and American scientists.

Why not pick up copies of Malignancy and Murder: A New Way to Lose Weight and see if you like how I incorporated science into my thrillers/mysteries?

I'll try to visit more often in 2015, but I've been busy preparing a collection of short stories.

# Main rule to include science in fiction. Use scientific details to create realistic scenes, but not so many as to slow the plot. http://jlgregerblog.blogspot.com

A Different View of Cuba

President Obama’s “new approach” on Cuba has intensified the debate on U.S.—Cuban relations. Would you like to learn a bit modern Cuba, besides all the politics?

Read the new thriller Malignancy. The plot in this fast-moving thriller is fiction but the background is based on documented scientific developments in Cuba and my observations during a visit to Cuba in November 2013.

Cuba is changing.

Among the propaganda spouted by Cuban tour guide in 2013 was the statement: Cuban scientists had patented a drug for cancer. When I got home, I found researchers in Havana had patented a therapeutic cancer vaccine to treat a rather rare type of lung cancer (non-small cell). In essence, the drug is supposed to rev up patients’ own immune systems to produce cells to slay the cancer cells without injuring the normal cells.

This patent demonstrates two facets of modern Cuba. Cuban scientists are doing competitive science. The Cuban government recognizes the importance of commercialization of their research. My guide’s comments suggest although Cubans are proud of their past, many think science and economic changes are important for their future.

The U.S. response to Cuba is surprising.

First off, I was amazed by the tons of consumer goods being flown by American Airlines from Miami into Cuba daily despite the embargo. I bet you’d be amazed, too, if you saw the baggage check in for flights to Havana.

I was also surprised to learn hundreds of Cuban scientists and artists had participated in non-U.S. government-sponsored exchanges already. In June 2014, the president of AAAS (American Association for the Advancement of Science) even requested U.S. government to sponsor scientific exchanges with Cuba. (Check out the editorial “Science diplomacy with Cuba” in the journal Science on June 6, 2014.)

My trip to Cuba turns into the thriller Malignancy.

Scientific exchanges were one of the early steps in the normalization of U.S. relationships with China in the 1970s. Similarly, the U.S. is apt to initiate more scientific exchanges with Cuba in the near future. I thought Sara Almquist, the epidemiologist and heroine of my previous medical thrillers Coming Flu and Ignore the Pain, would be the perfect protagonist to do a little “scientific diplomacy” in Cuba.

I wanted readers of Malignancy see more of Cuba than its scientific aspirations. So I have Sara to slip into La Floridita Bar, made famous by Hemingway, in Old Havana to meet a mysterious Cuban. Is he just a potential colleague, a spymaster, or both?

I suspect most Americans, including myself, know less about Cuban history than they realize. Accordingly, Sara discovers interesting quirks of Cuban history, as well as clues about those who are trying to kill her in Albuquerque, while she explores historic Colon Cemetery and Plaza de la Revolución in Havana.

So visit Cuba with Sara in Malignancy. Then you can decide if the personality of Havana matches your expectations.

Blurb for Malignancy: Men disguised as police officers shoot at Sara Almquist twice in one day. Albuquerque police suspect Jim Mazzone, a drug czar who has tangled with Sara before, will order more hits on Sara. Thus when colleagues in the State Department invite Sara to arrange scientific exchanges between the U.S. and Cuba, she jumps at the chance to get out of town and to see the mysterious Xave Zack, who rescued her in Bolivia. Maybe, she should question their motives.

The book is available from Amazon in paperback and Kindle versions.

Turning a Trip to Cuba into a Novel

I visited Cuba in 2013. My tour guide was determined for our group to see Cuba as more than a former haunt of mobsters from the U.S. and a place to see vintage U.S. cars. She bragged about how Cuba was modernizing its economy. I figured many of her comments were carefully rehearsed propaganda.

However, one of her claims caught my attention. She said Cuban researchers had patented a drug for cancer. When I got home, I checked. Researchers at the Center of Molecular Immunology in Havana and scientists in Argentina had developed a therapeutic cancer vaccine, called Racotumomab, to treat one type of lung cancer (non-small cell lung cancer). A multicenter clinical trail is now evaluating the drug’s effectiveness.

This drug is an example of a hot area of research – the development of cancer immunotherapy drugs, sometimes called cancer vaccines. These drugs rev up a patient’s own immune system to produce cells, which recognize substances found on the surface of tumor cells but not on the surface of normal cells. These cells then slay the cancer cells, but not the normal cells.

Okay that’s a heavy dose of science. Do these drugs work? The editors of Science named cancer immunotherapy the “scientific breakthrough of the year” in 2013. Hundred of labs worldwide are developing and patenting potential drugs of this sort. So far, none, including the Cuban one, have been a huge success. Several have helped patients to survive longer in clinical trials.

Why the fuss about this one Cuban patent? This patent demonstrates Cuban scientists are doing competitive science and understand the importance of commercialization of their research. I also discovered Cuban were already visiting American universities, and a number of U.S. scientists were trying to augment these scientific exchanges despite the U.S. embargo on Cuba.

I thought this could be the basis of a novel. Realistically the State Department might send (in the near future) scientists to Cuba to explore the possibility of creating government-sponsored exchanges between the two countries. Certainly scientific exchanges between the US and China were early steps in the normalization of our relationship with China during the Nixon administration.

The birth of MALIGNANCY: A Novel. I thought Sara Almquist, the epidemiologist and heroine of my previous medical thrillers Coming Flu and Ignore the Pain would be the perfect protagonist to do a little “scientific diplomacy” in Cuba. Besides, I could throw in a little intrigue about drugs slipping from Bolivia through Cuba and into the U.S.

Here’s a blurb on MALIGNANCY. Men disguised as police officers shoot at Sara Almquist twice in one day. The real police suspect Jim Mazzone, a drug czar who Sara has tangled with several times, will order more hits on Sara. Thus when colleagues in the State Department invite Sara to arrange scientific exchanges between the U.S. and Cuba, she jumps at the chance to get out of town. Maybe, she should question their motives.

I think you’ll find this novel has plenty of action and deserves thriller status. And it has something no other thriller has – a middle-aged woman heroine.